Efficacy and Safety of Canagliflozin

Question: Discuss about the Efficacy and Safety of Canagliflozin. Answer: Introduction: Mrs. Mallacota may be addicted to too much of sugary and fatty foods without performing any strenuous activities like exercises, that may lead to the development of excess fats in her abdominal area thus leading to the kidney diseases along with the development of the puffiness of the eyes. The past history may be of over-consumption of alcohol, taking non-healthy foods, taking excess amount of sugar (Burrow and Ride 2016). A normal kidney in a human contains 1 million nephrons, which contributes the total amount of in the filtrate rate of the glomerulus. Kidney has an innate ability in maintaining the healthy nephrons for manifestation of hyperfiltration and the compensatory hypertrophy. This adaptability of the nephrons focuses for the continuous in clearing the plasma solutes. The hyperfiltration along with the hypertrophy of the nephrons is noted as the major cause of the progressive dysfunction of the renal system. Type 1 diabetes is elaborated by a blend of edge at the resistant to insulin and deficit of it emission by pancreatic beta cells (Chin et al. 2014). Insulin resistance, which has been credited to raise levels of free unsaturated fats and star provocative cytokines in plasma, prompts to lessened glucose transport into muscle cells, lifted hepatic glucose creation, and extended breakdown of fat. The advice could be of reducing the sugar level in the blood, need to check the blood sugar content regularly. Being an aboriginal lady, Mrs. Mallacota is being advice to alter the food habit of low sugar content. Regular exercises along with the proper diet of diabetes type 1 as activities helps in reducing the blood sugar content in the blood along with the excess fats in the abdominal areas can helps in reducing the kidney disorder. The high levels of the blood sugar level forces kidney to function more and becomes harder for for the performing its function in filtering the wastes that also creates damage to the nephrons and it starts leaking small amount of proteins (Yale et al. 2014). Mrs Mallacota needs to manage herself on the field of Diabetes Type 1 by reducing the sugar-content in her diet. She needs to maintain her glycaemia level which will be help het in minimising hyperglycaemia with flexibility. Reference list: Burrow, S. and Ride, K., 2016. Review of diabetes among Aboriginal and Torres Strait Islander people.Mt Lawley (AUST): Edith Cowan University Australian Indigenous Health InfoNet. Chin, M.P., Reisman, S.A., Bakris, G.L., O'grady, M., Linde, P.G., McCullough, P.A., Packham, D., Vaziri, N.D., Ward, K.W., Warnock, D.G. and Meyer, C.J., 2014. Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.American journal of nephrology,39(6), pp.499-508. Inzucchi, S.E., Lipska, K.J., Mayo, H., Bailey, C.J. and McGuire, D.K., 2014. Metformin in patients with type 2 diabetes and kidney disease: a systematic review.Jama,312(24), pp.2668-2675. Yale, J.F., Bakris, G., Cariou, B., Nieto, J., David?Neto, E., Yue, D., Wajs, E., Figueroa, K., Jiang, J., Law, G. and Usiskin, K., 2014. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes mellitus and chronic kidney disease.Diabetes, Obesity and Metabolism,16(10), pp.1016-1027.